Pinealon

—

evidence score

peptide

Prescription Only

Glu-Asp-Arg

Tripeptide bioregulator (Glu-Asp-Arg) that stimulates pinealocyte function and melatonin synthesis. Promotes REM sleep architecture through pineal gland support rather than exogenous melatonin supplementation. Effects persist on non-injection nights.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal trials

Last Sync

Not synced yet

Last Reviewed

Not reviewed yet

Physician Notes

Stack with glycine 3-10g SubQ at bedtime for synergistic sleep effect. Effect persists on non-injection nights, suggesting structural benefit to pineal function. Better than exogenous melatonin long-term.

FDA Status:Currently available via 503A compounding pharmacies.

Monitoring

Sleep quality assessment
No specific labs required

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Dosing

Typical

200 mcg

100 mcgRange200 mcg

FrequencyDaily (before bed)

Set height & weight in Settings to see your dose.

Pharmacology

Half-lifeMinutes

OnsetSame night for sleep quality

Routes

subcutaneous_injection

intranasal

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(24%)—

Quality(24%)—

Sample Size(12%)—

Consistency(14%)—

Replication(8%)—

Recency(18%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Pinealon is currently categorized as a peptide compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

REM sleep bioregulator; stimulates pinealocytes for natural melatonin production

Practical Context

Strongest current signals

No indexed study summaries yet.