Methylated B Vitamins

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evidence score

vitamin mineral

MethylfolateMethylcobalaminL-methylfolate+1 more

Pre-methylated forms of B9 (L-methylfolate) and B12 (methylcobalamin) that bypass MTHFR enzyme variants. Support homocysteine metabolism, DNA methylation, neurotransmitter synthesis, and red blood cell production. Essential for patients with MTHFR mutations.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

Approved

Last Sync

Not synced yet

Last Reviewed

Not reviewed yet

Physician Notes

Target homocysteine <7. Mandatory with MOTS-c use (depletes folate cycle). MTHFR variants (C677T, A1298C) are common and impair folate metabolism. Always use methylated forms, not folic acid.

FDA Status:Available OTC and via prescription compounding.

Monitoring

Homocysteine q3-6mo (target <7)
B12 levels
Folate levels
MMA if B12 deficiency suspected

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Dosing

Typical

1 mg

1 mgRange15 mg

FrequencyDaily

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Pharmacology

Half-lifeVariable by form

Routes

oral

subcutaneous_injection

intramuscular_injection

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(24%)—

Quality(24%)—

Sample Size(12%)—

Consistency(14%)—

Replication(8%)—

Recency(18%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Methylated B Vitamins is currently categorized as a vitamin mineral compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Pre-activated B vitamins; bypass MTHFR variants for methylation support and homocysteine management

Practical Context

Strongest current signals

No indexed study summaries yet.